Credit: Lee Smith
Infertility Genes Could Lead to Male Contraception
Genes inِ charge ofِ making sperm cells mayِ beِ the key toِ understanding male infertility andِ even developing male contraception, twoِ newِ studies indicate.
Infertility remains a sensitive topic, andِ aboutِ 25 percent ofِ cases remain unexplained.
Getting a betterِ grasp onِ the genetic causesِ of infertile men couldِ lead toِ betterِ treatments, theِ researchers say.
The results, published today (May 24) inِ the American Journal ofِ Human Genetics, areِ based onِ a study ofِ the genetics ofِ a group ofِ men whoِ belong toِ a religious group called theِ Hutterites, pacifist, self-sufficient colonists similar toِ theِ Amish.
Hutterites forbid] contraception andِ uniformly desire large families, providing anِ outstanding population inِ which toِ study theِ genetics ofِ normal human fertility, study researcher Carole Ober ofِ the University ofِ Chicago explained inِ a statement.
They uncovered moreِ than 40 genetic regions thatِ influence howِ fertile a Hutterite man is, andِ then compared theseِ with genetic sequences fromِ a sample ofِ Chicago men, inِ which nineِ of theseِ sameِ regions seemedِ to impact fertility.
Smith andِ his colleagues fed drugs toِ mice thatِ gave themِ various genetic mutations.
Next, toِ pinpoint genes related toِ fertility, theِ researchers identified theِ infertile mice ofِ the bunch.
They thenِ traced theِ infertility backِ to theِ gene mistake thatِ caused itِ andِ looked atِ its effect onِ the mouse’s sperm cells.